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Research on the Mechanism by which Muscle-Derived Exosomes Accelerate Kidney Damage
  • 관리자
  • 2025-07-09
  • 233

A paper, 'Research on the Mechanism by which Muscle-Derived Exosomes Accelerate Kidney Damage', authored by a research team by Prof. Eunjung Jin(CEO), has been accepted for publication in Journal of Cachexia, Sarcopenia and Muscle(IF 9.4).

The research team experimentally demonstrated that exosome secreted after skeletal muscle injury travel through the bloodstream to reach damaged kidneys, where they selectively accumulate. They further identified a pathological pathway: the miR-21a-3p microRAN contained within these exosomes is delivered to kidney cells, suppressing the expression of the Ppargc1a gene. This, in  turn, inhibits the kidney's energy metabolism and antixidant system, ultimately exacerbating kidney damage.

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